Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1612735
rs1612735
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0236970
Disease:
Alcohol-Induced Disorders
T 0.700 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
dbSNP: rs1612735
rs1612735
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
T 0.700 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
dbSNP: rs1612735
rs1612735
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0236664
Disease:
Alcohol-Related Disorders
T 0.700 GeneticVariation GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
dbSNP: rs62307295
rs62307295
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C1445957
Disease:
Serum total cholesterol measurement
A 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs283415
rs283415
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0007102
Disease:
Malignant tumor of colon
0.010 GeneticVariation BEFREE In female drinkers, ADH1C rs283415 increased proximal colon cancer risk. 29390059 2018
dbSNP: rs283415
rs283415
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0699790
Disease:
Colon Carcinoma
0.010 GeneticVariation BEFREE In female drinkers, ADH1C rs283415 increased proximal colon cancer risk. 29390059 2018
dbSNP: rs4147542
rs4147542
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0007102
Disease:
Malignant tumor of colon
0.010 GeneticVariation BEFREE ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women. 29390059 2018
dbSNP: rs4147542
rs4147542
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0699790
Disease:
Colon Carcinoma
0.010 GeneticVariation BEFREE ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women. 29390059 2018
dbSNP: rs141973904
rs141973904
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001956
Disease:
Alcohol Use Disorder
0.010 GeneticVariation BEFREE The gene ADH1C, which has been previously implicated in AUD, was among our most significant associations (4.4 × 10<sup>-7</sup> ; rs141973904). 29058377 2019
dbSNP: rs1693482
rs1693482
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0683342
Disease:
hazardous drinking
0.010 GeneticVariation BEFREE This study investigated the association of 4 nonsynonymous SNPs in ADH genes (Arg48His and Arg370Cys in ADH1B gene; Arg272Gln and Ile350Val in ADH1C gene) with HD in people living with HIV-1. 28833276 2017
dbSNP: rs35385902
rs35385902
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0683342
Disease:
hazardous drinking
0.010 GeneticVariation BEFREE The results of this study suggest a possible effect of the Arg48His genotype on the protection against HD in HIV-1-positive individuals. 28833276 2017
dbSNP: rs67420531
rs67420531
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0683342
Disease:
hazardous drinking
0.010 GeneticVariation BEFREE This study investigated the association of 4 nonsynonymous SNPs in ADH genes (Arg48His and Arg370Cys in ADH1B gene; Arg272Gln and Ile350Val in ADH1C gene) with HD in people living with HIV-1. 28833276 2017
dbSNP: rs698
rs698
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0683342
Disease:
hazardous drinking
0.010 GeneticVariation BEFREE This study investigated the association of 4 nonsynonymous SNPs in ADH genes (Arg48His and Arg370Cys in ADH1B gene; Arg272Gln and Ile350Val in ADH1C gene) with HD in people living with HIV-1. 28833276 2017
dbSNP: rs1789924
rs1789924
Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
T 0.700 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907 2017
dbSNP: rs1789924
rs1789924
Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0236664
Disease:
Alcohol-Related Disorders
T 0.700 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907 2017
dbSNP: rs1789924
rs1789924
Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0236970
Disease:
Alcohol-Induced Disorders
T 0.700 GeneticVariation GWASCAT Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. 28714907 2017
dbSNP: rs698
rs698
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.050 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454 2018
dbSNP: rs35385902
rs35385902
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.020 GeneticVariation BEFREE Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. 28610454 2018
dbSNP: rs698
rs698
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.050 GeneticVariation BEFREE The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. 27172571 2016
dbSNP: rs698
rs698
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0030305
Disease:
Pancreatitis
0.010 GeneticVariation BEFREE Numerous studies have focused on the relationship be-tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. 26634490 2015
dbSNP: rs698
rs698
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.050 GeneticVariation BEFREE To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample. 25372623 2015
dbSNP: rs4147541
rs4147541
Entrez Id: 126
Gene Symbol: ADH1C
ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs. 24889829 2014
dbSNP: rs4147542
rs4147542
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs. 24889829 2014
dbSNP: rs1614972
rs1614972
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.010 GeneticVariation BEFREE In the study, we examined the association between five ADH1B-ADH1C-ADH7 cluster SNPs (rs1042026, rs17033, rs1614972, rs1789903 and rs17028973) and risk of developing ESCC. 24722735 2014
dbSNP: rs1789903
rs1789903
Entrez Id: 125;126
Gene Symbol: ADH1B;ADH1C
ADH1B;ADH1C
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus
0.010 GeneticVariation BEFREE In the study, we examined the association between five ADH1B-ADH1C-ADH7 cluster SNPs (rs1042026, rs17033, rs1614972, rs1789903 and rs17028973) and risk of developing ESCC. 24722735 2014